952 A NEW GENETIC DISORDER OF NEUTROPHIL OXIDATIVE METABOLISM
نویسندگان
چکیده
منابع مشابه
Inhibition of neutrophil oxidative metabolism by lysosomotropic weak bases.
Maintenance of an acidic intralysosomal compartment may be relevant to multiple aspects of neutrophil function. The effect of lysosomal alkalinization on the neutrophil respiratory burst was studied by measuring cytochrome c reduction in response to soluble stimuli in the presence of lysosomotropic weak bases. The weak bases chloroquine, ammonium chloride, methylamine, and clindamycin all raise...
متن کاملInhibition of neutrophil oxidative metabolism by lysosomotropic weak
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متن کاملNeutrophil migration, oxidative metabolism and adhesion in early onset periodontitis.
The aim of this study was to evaluate neutrophil function in patients suffering from the generalized form of early onset periodontitis (EOP). We investigated neutrophil migration in vivo and neutrophil superoxide production and adhesion in response to a variety of compounds; neutrophils were isolated both from blood and a skin experimental exudate of 15 patients with EOP and of 15 sex- and age-...
متن کاملA disorder of surfactant metabolism without identified genetic mutations
BACKGROUND Surfactant metabolism disorders may result in diffuse lung disease in children. CASE PRESENTATION We report a 3-years-old boy with dry cough, progressive hypoxemia, dyspnea and bilateral ground glass opacities at chest high-resolution computed tomography (HRCT) who had no variants in genes encoding surfactant proteins or transcription factors. Lung histology strongly suggested an a...
متن کاملInhibition of zymosan activation of human neutrophil oxidative metabolism by a mouse monoclonal antibody.
We have studied a neutrophil-specific murine monoclonal antibody, PMN7C3 (IgG3), which specifically alters PMN oxidative metabolism stimulated by serum-opsonized zymosan (STZ) or Candida albicans (STC). Polymorphonuclear cells (PMNs) exposed to PMN7C3 show a significant depression in O2- release (52.8% +/- 2.5% of control), H2O2 release (44.4% +/- 6.0% of control), and O2 consumption (73.9% +/-...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-00982